Stimulation of basalganglia neurons in-vitro


To investigate neuronal in vitronetworks with an approach combining multi-electrodearrays (MEA) and the patch-clamp techniqueto widen our knowledge on thecellular mechanisms of deep brain stimulation.


Peer-reviewed journal papers:

  • BUEHLER, S. M., STUBBE, M., BONK, S. M., NISSEN, M., TITIPORNUN, K., KLINKENBERG, E.-D., BAUMANN, W. and GIMSA, J., 2016. Cell Monitoring and Manipulation Systems (CMMSs) based on Glass Cell-Culture-Chips (GC3s). Micromachines, 7 (7), pp. 106. DOI: 10.3390/mi7070106.
  • NISSEN, M., BUEHLER, S. M., STUBBE, M. and GIMSA, J., 2016.  Neuronal in-vitro activity is more sensitive to valproate than intracellular ATP: Considerations on conversion problems of IC50 in vitro data for animal replacement. BioSystems, 144, pp. 35-45. DOI:10.1016/j.biosystems.2016.04.009.
  • STUBBE, M., NISSEN, M., SCHROEDER, J. and GIMSA, J., 2015. The effect of hyperbaric air on the electric activity of neuronal in vitro networks. Biosensors and Bioelectronics, 73, pp. 153-159. DOI:10.1016/j.bios.2015.05.052.
  • NISSEN, M., SHCHERBAKOV, D., and HEYER, A., 2015. Behaviour of the plathelminth Symsagittifera roscoffensis under different light conditions and the consequences on the symbiotic algae Tetraselmis convolutae. The Journal of Experimental Biology. S. jeb.110429, DOI: 10.1242/jeb.110429.

Peer-reviewed paper important congresses:

  • NISSEN, M., BÜHLER, S., STUBBE, M., BAUMANN, W., GIMSA, J., 2014. Biphasic Response of Neuronal Networks to Sodium Valproic Acid (NaVPA). Proceedings MEA Meeting, pp. 126. ISSN: 2199-1596.
  • NISSEN, M., BUEHLER, S.M., BONK, S., STUBBE, M., REIMER, T., BAUMANN, W. and GIMSA, J., 2012. Sensors for Glass Cell-Culture Chips (GC³). A. Stett, G. Zeck (Eds.) Proceedings MEA Meeting 2012, NMI, Univ. of Tübingen, Reutlingen, pp. 290.